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However, numerous randomized controlled trials have demonstrated that supplementation with a combination of vitamin B 6 , vitamin B 12 , and folic acid lowers homocysteine levels in individuals with vascular dysfunction or hyperhomocysteinemia

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[DOI] [PubMed] [Google Scholar] van de Bank B.L., Emir U.E., Boer V.O., van Asten J.J.A., Maas M.C., Wijnen J.P., Kan H.E., Oz G., Klomp D.W.J., Scheenen T.W.J