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In preclinical work, researchers have associated it with angiogenesis, the formation of new blood vessels, through pathways involving VEGFR2 and nitric oxide signaling

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For each patient, the following was reviewed: • Current repeat prescription DOSE and indication • Patient AGE • Patient WEIGHT • Patient SERUM CREATININE (ensuring up to date U&E) • Patient CrCl For AF dosing, patients must meet the CrCl threshold or TWO of the other criteria to require dose reduction