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However, excessive ROS production overwhelms antioxidant systems, leading to lipid peroxidation, protein and DNA damage, and impaired placental function

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Future trials should aim to stratify by baseline B 12 levels, explore genetic moderators of response (e.g., Methylenetetrahydrofolate Reductase—MTHFR polymorphisms), and extend follow-up durations to examine sustained neurodevelopmental outcomes