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Studies have consistently reported that inhibiting NNMT activity or downregulating NNMT expression leads to significant increases in NAD + levels in mouse adipocytes ( + levels ( in vitro experiments that NNMT promotes the migration and invasive ability of esophageal squamous cell carcinoma (ESCC), and NNMT also promotes the process of epithelial mesenchymal transition (EMT) by affecting the post-transcriptional modification of E-calmodulin

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