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The combined pharmacokinetic consequence of these four substitutions is a GHRH(1-29) analogue with a half-life of around 30 minutes and representing a ten-fold or greater extension compared to native GHRH’s minutes-long circulating life , while maintaining full GHRH receptor binding affinity confirmed by receptor binding assays and full pituitary GH-releasing activity confirmed by GH secretion studies

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Scherber RM, Geyer HL, Dueck AC, Kosiorek HE, Finazzi G, Cavazzina R, et al