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Excess extracellular glutamate triggers mechanisms involving astrocyte-mediated inflammation, including the release of Ca 2+ -dependent glutamate from astrocytes, the appearance of excitotoxicity, the formation of reactive oxygen species (ROS), and cell damage
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10.2174/1570159X22666231103085859 Summary Keywords deuterium, copper, histidine, amyloidogenic proteins, cardiolipin, mitochondrial dysfunction, neurodegeneration Citation Seneff S and Kyriakopoulos AM (2025) Deuterium trafficking, mitochondrial dysfunction, copper homeostasis, and neurodegenerative disease