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That said, the following may occur: → Mild water retention or bloating → Headaches (from fluid shifts or blood pressure changes) → Temporary hunger increases (due to GH release) → Injection site irritation → Cortisol & Prolactin Unlike older GHRPs like GHRP-2 or GHRP-6 , Ipamorelin does not significantly raise cortisol or prolactin , two hormones associated with water retention, fatigue, gynecomastia, and mood instability