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Peptide inhibitors targeting FOXO4-p53 interactions and inducing senescent cancer cell-specific apoptosis | bioRxiv

Moreover, Gln is an essential substrate for the immune system, and prolonged use of Gln metabolic inhibitors might weaken the anti-tumor immune response (9, 12)

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It seems that GSH sacrifices itself to regenerate other antioxidants and a large amount of GSH is consumed as a direct antioxidant and also in recycling other antioxidants