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Vitamin B12 monitoring is not routinely indicated for patients on GLP-1/GIP therapy alone but may be considered for those also taking metformin or with risk factors for deficiency

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In line with previous observations, that AMP formation surpasses ADO clearance (48), we found in a cohort of newly diagnosed MM patients that BM ADO concentrations range from ~25 μM in MGUS/SMM to 25-250 μM in active MM, with particularly elevated levels in ISS stage 3 (45)