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Early control can delay urinary protein increase and renal function decline in DM patients 30 , for instance, a 40% increase in the risk of microalbuminuria is associated with a 10% decrease in time in range (TIR), which reflects blood glucose fluctuation 31

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Curcumin enhances beneficial microbiome, involving lactobacilli, bifidobacteria, and butyrate - forming bacteria, while promoting intestinal barrier integrity through immunomodulatory effects (569, 570)