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For example, PRMT1 overexpression is associated with increased arginine methylation and aberrant exon inclusion of SRSF1, which is essential for breast cancer cell growth [47]

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Then, the rate-limiting enzyme in arginine synthesis, argininosuccinate synthetase 1 (ASS1), catalyzes the conversion of citrulline and aspartate into argininosuccinate, which is then cleaved into arginine and fumarate by argininosuccinate lyase (ASL) (Figure 1)