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Finally, although more work is needed, our data may lead to a new concept in degrader drug discovery that inhibiting these cell-intrinsic inhibitory pathways may improve the efficacy of targeted protein degradation

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Importance of the Intrarenal Renin-Angiotensin System and Endothelin The RAAS, especially the intrarenal RAS, plays a significant role in developing and maintaining HTN in experimental models, including SHR, Ang II-induced HTN, and Dahl SS HTN [72]

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