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Beyond cystine import, the ferroptosis evasion machinery encompasses the upregulation of critical antioxidant enzymes, notably GSH and GPX4, which are consistently upregulated across multiple tumor types (137,138)

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The respective proportion of patients with recovery was 44.50% (77/173) in the acupuncture combined with vitamin B 12 group and was 62.57% (107/171) in the acupuncture alone group