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The TrxR1/Gsr-null hepatocytes exhibit robust proliferation during postnatal liver growth and during regeneration following surgical partial hepatectomy [107]

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Although the primary abnormalities in this disorder are short stature/poor growth velocity in nearly 100% and primary ovarian failure in ~85% of girls with TS, other stigmata may be present at varying (but fairly low) frequencies, including webbed neck, low-set pinnae, low posterior hair line, shield- shaped chest, widely-spaced nipples, and increased carrying angles (cubitus valgus)