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The ALA doses were hypothesized from extrapolation of the PK ALA data 43 that parenteral dosing with 50 mg/kg should yield ~0.80 mM plasma Cmax, a 30 mg/kg dose should yield ~0.50 mM, a 20 mg/kg dose should yield ~0.30 mM, and 10 mg/kg dose should yield ~0.10 mM plasma Cmax

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While we now have some understanding of how the supporting mesenchyme guides the differentiation of the epithelium, much less is known about the metabolism of the intestinal mesenchyme

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