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To investigate this, we performed CRISPR–Cas9-based genetic screens in both Jurkat and HEK 293T cells using a metabolism-focused single guide RNA (sgRNA) library 17 and screened for genes essential for cellular proliferation in the absence of SLC25A39 (Fig

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While methylcobalamin, hydroxycobalamin, and adenosylcobalamin offer unique benefits, cyanocobalamin may be less suitable for those with severe conditions