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Bruton’s tyrosine kinase and protein kinase C μ are required for TLR7/9-induced IKKα and IRF-1 activation and interferon-β production in conventional dendritic cells

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Upon sensing environmental stress or cellular damage, the absent in melanoma 2 inflammasome (AIM2) and NLR family pyrin domain-containing 3 (NLRP3) inflammasome assemble and recruit the inflammasome adapter protein apoptosis-associated speck-like protein containing CARD, leading to the activation of pro-inflammatory caspases [137]