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Acknowledgements This work was supported by grants from the Shenzhen Medical Academy of Research and Translation, Shenzhen, China (A2303031 to Shu Yang), the National Natural Science Foundation of China, China (82370876 to Shu Yang, 82170842 and 82371572 to Zhen Liang, 82171556 to Lin Kang, 82460150 to Xinyu Wang), National Science and Technology Major Project for the Prevention and Treatment of Cancer, Cardiovascular and Cerebrovascular, Respiratory and Metabolic Diseases, China (2024ZD0524800 and 2024ZD0524803), and Shenzhen Medical Research Fund, Shenzhen, China (C2406001)