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Decreased pup body weight on days 7, 14, and 21 of lactation at maternally toxic doses, rats Lowest relevant reproductive NOAEL 10 mg/kg bw per day Developmental target/critical effect Increased incidence of skeletal malformations, rabbit Lowest relevant developmental NOAEL Rabbit, 20 mg/kg bw per day Neurotoxicity/Delayed neurotoxicity No evidence of neurotoxicity Medical data None Summary Value Study Safety factor ADI 0-0.02 mg/kg bw Two 2-year studies in rats 100 Acute reference dose 0.02 mg/kg bw Skeletal malformations in rabbits 1000 References Babish, J.G

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Lio et al