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As no data are available on efficacy of this formulation, we studied vitamin B12 serum levels, the physical activity scale of the RAND-36, the number of steps on an activity meter, and the fatigue and concentration scales of the CIS20r questionnaires, before and after 3 months of treatment in ME/CFS patients

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The study, however, only examined a short-term (7-day) inhibition of pathological angiogenesis, which does not mimic a typical clinical treatment strategy, where treatment typically lasts for several weeks or months