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Because the distribution of the calculated difference within and between each study group failed to demonstrate a normal distribution, the median value and 95% CI were used for description, and the Wilcoxon signed-rank test (nonparametric test equivalent to dependent t test) was calculated

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Oral Bioavailability and Metabolic Stability Many bioactive constituents derived from TCM, particularly glycosides (eg, paeoniflorin, forsythoside A) and alkaloids (eg, berberine), exhibit poor oral bioavailability attributable to limited gastrointestinal stability, efflux transporter involvement, and extensive Phase II metabolism including glucuronidation and sulfation