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Chronic neuroinflammation arises when persistent stimuli, including genetic mutations, pathological protein aggregates (e.g., Aβ and α-synuclein), traumatic injury, or neurotoxic exposure, convert an otherwise transient, protective inflammatory response into a sustained and maladaptive state
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80% of women with PCOS have elevated serum androgen levels ( κ B (NF- κ B) is a potential crucial mediator of hyperandrogenemia-induced inflammation ( in vitro , which may be an important factor in promoting HA in PCOS ( Metabolic Disorders and Oxidative Stress MetS is a complex group of metabolic disorders in which the metabolism of proteins, fats, carbohydrates, and other substances in the human body is disturbed