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The capsaicin pretreatment was also effective in the reversal of esophagoprotection induced by melatonin and such capsaicin deactivation of sensory nerves by capsaicin significantly reduced plasma NOx suggesting that sensory nerves contribute to the esophageal protection mainly by stimulation of NO generation possibly via releasing sensory neuropeptide such calcitonin gene-related peptide (CGRP) that is known to stimulate the activity of NOS and release of NO, protecting the mucosal lining of GIT (45)