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Cytoplasmic IDH1 and mitochondrial isocitrate dehydrogenase 2 (IDH2) reversibly synthesize α-ketoglutarate from isocitrate and function in the reversible mitochondrial citrate-α-ketoglutarate shuttle (CAS) that shuttles NADPH reducing equivalents between the cytoplasm and the mitochondrial matrix (Figure 2D)

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Figure 2 Table 1 Summary of studies concerning the alterations of the gut microbiota in AD