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Acknowledgements The research program in our laboratory is supported by the Wellcome Trust DBT India Alliance (IA/I/13/2/501023) and Centre of Excellence grant BT/PR15450/COE/34/46/2016 from Department of Biotechnology, India

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Protein folding in the endoplasmic reticulum (ER) is a critical cellular function and various cellular stresses such as ROS or alterations in cellular calcium can impair protein folding and initiate ER stress