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The HO-1 ferritin system Cells exposed to free heme or heme-releasing Hb species, i.e., metHb and oxHb up-regulate HO-1 and ferritin (Figure 1) (Balla et al., 1992

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It was first described in the early 1990s, and since then has been extensively studied in preclinical models for its effects on tissue repair, angiogenesis, and gastrointestinal function