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For example, loss of heterochromatin and histones in aging yeast cells promotes transcriptional dysregulation and contributes to the development of genomic instability, increasing DNA breaks, translocations, and mitochondrial DNA insertions (Pa et al., 2016)

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Quantitative assessment of fitting performance was made using Euclidian distance between “stick” vectors (scaled by “fiber” fraction) estimated to those generated from ground truth parameters