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Another area of active research is the development of stimuli-responsive liposomes, which are designed to release their cargo under specific environmental conditions, such as changes in pH, redox potential, or temperature [317]

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Although exogenous fatty acids are required for glucose-stimulated insulin secretion in the isolated islet, an excess of fatty acids can be detrimental to the beta cell, resulting in “lipotoxicity.” Although the precise mechanism of this effect remains uncertain, high levels of FFAs correlate with beta cell dysfunction in models of type 2 diabetes (15)