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Here, we demonstrate that the GST tag is a substrate of transglutaminase 2 (TG2), which is a calcium-dependent enzyme that polyaminates or crosslinks substrate proteins

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It is found in high concentrations in the liver, where it binds to heavy metals, such as mercury and lead, chemical pollutants and carcinogens, and then transforms them into a form that can be easily flushed out of the body via enzymatic pathways