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In the PK tetramer, subunit interactions at the interfaces between A and C domains, as well as A/B and A/C domain interactions within one subunit, are considered to be key determinants of the allosteric response, involving switching from the low-affinity T-state to the high affinity R-state

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Spleen Spleen is one of the richest natural sources of bioavailable iron, surpassing even liver in certain cases