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doi: 10.3390/antiox11102071

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however, there are four overarching steps that are essential in GC dysfunction: a) reduced GR expression, b) defective binding of steroids to the receptor, c) reduced ability of the receptor to bind to the DNA, either due to competition or reduced nuclear translocation, and d) increased expression and antagonism from proinflammatory transcription factors (AP-1 and NFκB)