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The study also examined the percentage of time spent in “off” periods, which are times when medication effectiveness decreases and PD symptoms worsen

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No potential mutagenicity of tesamorelin acetate was revealed in a battery of tests including induction of gene mutations in bacteria (the Ames test), gene mutations in mammalian cells grown in vitro (hamster CHOK1 cells), and chromosomal damage in intact animals (bone marrow cells in mice)