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The critical need for GSH is consistent with its role as a cofactor for mitochondrial glutaredoxins, which are conserved oxidoreductases involved in iron–sulfur cluster biogenesis 31

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Recently, however, the activity of other ALDH isozymes, including ALDH1A2, ALDH1A3, ALDH1A7, ALDH2, ALDH3A1, ALDH4A1, ALDH5A1, ALDH6, and ALDH9A1, have shown to contribute to the elevated ALDH activity observed in cancer stem cells [150, 151]