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The involvement of l-arginine-NO system in the central regulation of reproduction has been documented by demonstrating the presence of neuronal NOS in the somatostatin neurons in the ventral medial nucleus of the hypothalamus [42]

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Chronic traumatic encephalopathy and other forms of dementia have been linked to repetitive mild TBI caused by sports related concussive and subconcussive head trauma in football, hockey, soccer, and wrestling (Guskiewicz et al., 2005