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The Ultimate Liposomal Glutathione Guide – Intelligent Labs

In the HR repair pathway, DSB is first recognized by ataxia-telangiectasia mutated (ATM) or ATM- and Rad3-Related (ATR) and recruits MRE11, RAD50, and NBS1 to form Mre11-Rad50-Nbs1complex (MRN) complex, MRN shears the terminal DNA to form single-strand DNA (ssDNA), ssDNA is encapsulated by replication protein A (RP-A) thus preventing it from being degraded by nuclease, and then through a series of complex regulation, the terminal complex is covered by RP-A and replaced by DNA damage repair protein 51 (RAD51) to form nucleoprotein filament

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