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Trypanosoma brucei parasites occupy and functionally adapt to the adipose tissue in mice

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It accumulates as unmetabolized folic acid (UMFA) and competes with active folates for receptors.¹ Conversion between the two active forms is unreliable : it requires multiple enzymes (MTR, MTRR, SHMT, MTHFR, MTHFS) all working properly, and is easily blocked by low glutathione, B12 deficiency, heavy metals, or oxidative stress