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More information about the COPDGene Study and a list of publications can be found at: Measuring antioxidant gene expression in various cell types in COPD As the primary site of the disease in COPD is the lung, most often the antioxidant gene expression is measured in lung tissue (36, 44, 48, 49, 51, 53, 55–57, 59, 60, 65, 73, 80, 97) commonly the interest is shifted mainly to alveolar macrophages because they play a crucial role in the pathogenesis of COPD (36, 44, 53, 57, 60, 73) but also bronchial and airway epithelium (44, 53, 57, 60, 65, 73)