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For instance, while studying HCC, researchers showed that HGF triggered activation of c-Met, which resulted in simultaneous phosphorylation and expression of Caveolin1 (an integral membrane protein involved in signal transduction), while overexpression of Caveolin1 promoted the c-Met signaling pathway (Korhan et al., 2014)

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FBXO7 has an N-terminal ubiquitin-related (UBR) domain that participates in the regulation of mitochondrial quality control through interaction with parkin (Zhou et al., 2016)