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A separate 2025 narrative review by McGuire and colleagues asked a blunter question in its title: "Regeneration or Risk?" [2] Their conclusion: the preclinical evidence is consistently positive, but the absence of human data makes it impossible to generate evidence-based practice guidelines

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A study has shown that, under conditions of excess iron, ox-LDL and LPS/IFN-γ stimulation in the vascular microenvironment, the proportion of M1 macrophages increases markedly

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