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ROS including superoxide anions (O 2 •– ), hydroxyl radicals (OH • ) and hydrogen peroxide (H 2 O 2 ) are produced by endothelial cells, inflammatory cells and the mitochondrial electron transport system

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This “cytokine storm” promotes a self-sustained inflammatory reaction which, contributing to the destruction of the endothelium, leads to “acute respiratory distress syndrome”, multiple organ failure, and death