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Funding This work was supported by grants from the National Natural Science Foundation of China (82273367), Joint Funds for the innovation of science and Technology, Fujian province (2020Y9131), the Natural Science Foundation of Fujian Province (2024J09033), the Excellent Youth Training Program of the First Affiliated Hospital of Fujian Medical University (2023FY-YXQN-2), the Fujian Provincial Health Technology Project (2024GGB07)

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In summary, although IBD is a multifactorial disease in which activation of inflammatory cells is thought to play a key role for its development, the synergism between ROS generation and subsequent GSH depletion induced by TNBS appears to be a key event, at least in this model of acute colitis induced by TNBS+ethanol