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systematically categorized epigenetic resistance mechanisms by regulatory modalities (DNA methylation, RNA regulation, histone modification, chromatin remodeling), emphasizing epigenetic-targeted agents (e.g., DNMT/HDAC inhibitors) and their clinical potentia [13]
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A critical factor complicating this translation is the significant heterogeneity in methodological variables (including the choice of animal species, model type, and ischemia duration) across preclinical studies