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Ipamorelin's pentapeptide backbone is not unusually labile, but in aqueous solution at room temperature, measurable degradation accrues over days to weeks

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In a previous randomised, placebo-controlled trial, de Jager et al (2010) added metformin 850 mg three times daily to insulin therapy (a higher metformin dose than is usually now used) and demonstrated a number needed to harm of just under 14 for development of B12 deficiency over the 4.3 years of the trial