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Treatment with A2ARi or with A2ARi plus Lip-1 resulted in a significant reduction of exhausted-like phenotype in activated OT-1 CD8 + T cells in the cultures (Figure 4F), while the stem-like phenotype (expressing TCF1 and CD44) (Figure 4G) and memory phenotype (expressing CD127 [IL-7Rα] and CD44) (Figure 4H) were increased upon treatment with Lip-1 or with Lip-1 plus A2ARi in comparison with control CD8 + T cells