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Some commenters noted that requiring renewing ACOs to move into downside risk before they are ready could destabilize the Shared Savings Program, and an exception to the proposed policy (requiring participation in Level E of subsequent BASIC track agreements) would ensure that the ACOs assume risk after 7 years as originally anticipated, albeit a lower level of risk

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Seven highly effective EGFR binding ligands have been identified to trigger such canonical downstream effects: EGF, transforming growth factor-α (TGF-α), heparin-binding epidermal growth factor (HB-EGF), amphiregulin (AREG), betacellulin, epiregulin, and epigen [179]