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Coronaviruses may induce several redox sensitive proinflammatory pathways such NF-kB, mito-ROS and NOX pathways and downregulate anti-inflammatory ACE2 and Nrf2 pathways

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For example, recent studies showed a relationship between rs12201199 in thiopurine S-methyltransferase gene ( TPMT ) and rs9332377 in the catechol-O-methyltransferase gene ( COMPT ) with cisplatin-induced hearing loss in children (Ross et al., Finally, prospective clinical studies employing polymorphism panels in these treatment procedures are required to determine whether adjustment of therapy based on genetic information can influence outcomes in these scenarios