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After cell death, nucleosomes are released into the blood, modified by some enzymes, and are then referred to as “circulating cell-free nucleosomes” (CCFN) (141)

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Iron overload-induced ferroptosis has been increasingly recognized as a critical contributor to the pathogenesis of multiple fibrotic diseases, including hepatic fibrosis [20], renal fibrosis [21], radiation-induced intestinal fibrosis [22], myocardial fibrosis [23], and PF [24]