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This was taken as an effective upgrade of the cytoprotection principle of endothelium maintenance → epithelium maintenance [5,6,66,71,72,73,74,75,76,77,78,79,80,81,82] (note, long ago, the principle of cytoprotective agents’ pleiotropic beneficial activities postulated the founding of two major groups of (stomach) studies: Robert (epithelium maintenance) and Szabo (endothelium maintenance) [35,36,37,38,39,40,41,42] (for review, see [32,33,34])

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Th2 cells secrete IL-4 and IL-13 to induce ASMC proliferation and mucus secretion, with glycolysis-dominated metabolism further amplifying airway remodeling signals (7, 41)