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The contributions of excitotoxicity, glutathione depletion and DNA repair in chemically induced injury to neurones: exemplified with toxic effects on cerebellar granule cells - Fonnum - 2004 - Journal of Neurochemistry - Wiley Online Library

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The greatest challenge with IVIVE underprediction is that the degree of underprediction can vary greatly from drug-to-drug, and the field does not yet understand why