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Key Takeaways HCPCS code J3370 (injection, vancomycin HCl, 500 mg) was deleted effective June 30, 2025, as part of CMS’s Q3 2025 HCPCS Level II quarterly update The direct replacement is HCPCS code J3373 (injection, vancomycin hydrochloride, 10 mg), effective July 1, 2025, billed per 10 mg administered instead of per 500 mg J3371 (Mylan formulation) and J3372 (Xellia formulation) were deleted the same day and replaced by J3374 and J3375, both also billed per 10 mg Billing J3373 with the old 500 mg-per-unit math undercounts badly: a 1,000 mg dose is J3373 x 100 units, not x 2, and there is no grace period for claims still carrying the deleted J3370 Pabau’s claims management software helps outpatient infusion practices update their charge master to J3373 and flags a deleted code like J3370 before a claim goes out If your charge master still lists HCPCS code J3370, it’s out of date
